![]() ![]() Clinicians should be aware of the multi-system complications that are associated with CP and which may present significant diagnostic challenges given that many children with CP communicate non-verbally. Additionally, several biomarkers hold promise in assisting with long-term monitoring. MOD in CP has not yet been quantified and a scoring system may prove useful in allowing advanced clinical planning and follow-up of children with CP. ![]() It may also contribute to an improved understanding of the etiology and thus may have an implication in prevention, interventional methods and therapies. Assessment of multi-organ function may help to prevent complications in later childhood or adulthood. Therefore, CP should not be seen as an unchanging disorder caused by a solitary insult but rather, as a condition which evolves over time. Alongside this, there has been increasing recognition of the multi-organ dysfunction (MOD) associated with CP, in particular in children with higher levels of motor impairment. Our understanding of the underlying cause of CP has developed significantly, with areas such as inflammation, epigenetics and genetic susceptibility to subsequent insults providing new insights. Each case requires detailed consideration of etiology. CP is an umbrella term for a heterogenous condition and is, therefore, descriptive rather than a diagnosis. 11Department of Neonatology, The Coombe Women and Infants University Hospital, Dublin, IrelandĬerebral Palsy (CP) describes a heterogenous group of non-progressive disorders of posture or movement, causing activity limitation, due to a lesion in the developing brain.10Department of Paediatrics, Cork University Hospital, Cork, Ireland.9Central Remedial Clinic, Dublin, Ireland.8Children's Health Ireland at Temple St.7Children's Health Ireland at Crumlin, Dublin, Ireland.6Royal College of Surgeons in Ireland, Dublin, Ireland.5Department of Clinical Genetics, Birmingham Women's Hospital, Birmingham, United Kingdom.3Children's Health Ireland (CHI) at Tallaght, Dublin, Ireland.2Trinity Research in Childhood Centre, Trinity College Dublin, Dublin, Ireland.1Discipline of Pediatrics, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland.John Allen 1,2,3 Zunera Zareen 4 Samantha Doyle 5 Laura Whitla 6 Zainab Afzal 1 Maria Stack 7,8 Orla Franklin 7,8 Andrew Green 7,8 Adam James 3,7 Timothy Ronan Leahy 1,7 Shoana Quinn 3 Basil Elnazir 3 John Russell 7 Sri Paran 7 Patrick Kiely 7 Edna Frances Roche 1,2,3 Ciara McDonnell 1,2,3,8 Louise Baker 8 Owen Hensey 9 Louise Gibson 10 Stephanie Kelly 3 Denise McDonald 3 Eleanor J. ![]()
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